RE: Intradialytic hypertension 48 minutes ago

Folks: does any one know the effect of high frequency radio-ablation of renal nerves in some one who has presumed ESRD but good residual function? ...

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RE: IgA, Gd-IgA, 53 minutes ago

Thanks Dr Glassock , so today we don't have to evaluate with this Ig GD1 the possibility of relapse Ig A nephropathy in kidney transplant . We need...

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RE: IgA, Gd-IgA, 1 hour ago

Dr. Munoz. Thanks. Please note that serum levels of antibody to gdIgA were NOT studied in this paper. Whether reductions in the serum levels of gdI...

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RE: IgA Nephropathy Dual Immunotherapy 1 hour ago

I don't disagree with your hypothesis that the increase in GFR seen after anti-inflammatory drug therapy of IgAN might be the consequence if an inc...

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RE: Intradialytic hypertension 1 hour ago

This is interesting, was not aware that plasma refill rates can exceed UF rate and also wonder what would be the mechanism. I have always thought t...

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IgA, Gd-IgA, 1 hour ago

Thank You Dr Glassock I share interesting articles recently published Kidney international Thanks again Files Attached DocumentIgA, Gd-IgA,

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RE: IgA Nephropathy Dual Immunotherapy 1 hour ago

Conceding that its no small presumption; some of this increase in snGFR may be due to resolution of endocapillry hypercellularity, resoprtion of me...

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RE: AI in Nephrology Conference April 23-24 1 hour ago

Hi Melisa, I hope you are doing well I am Renal Fellow from Elmhurst Hospital Center NY, I am planning to join AI in Nephrology Conferenc...

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Glomerular Disease Fellowship Spots 2 hours ago

Hello ASN Community, Can someone please share the updated list of Institutes offering Glomerular disease Fellowship in the United States. Some...

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RE: Ig A nephropathy 3 hours ago

I am not sure that I understand your question. As far as I know, there are no studies that link the levels of anti-gd IgA antibody and recurrence o...

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Ig A nephropathy 5 hours ago

In patient with Ig A nephropathy is possible measure levels of Ac anti Gd1 in receptor to evaluate the possibility of relapse of this pathology in ...

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RE: IgA Nephropathy 13 hours ago

I agree with periodic bacteremia surveillance as pt might have "Endotipsitis" that is not well managed. See if ID could review as well. There is ...

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RE: Pembrolizumab (Keytruda) AIN question 15 hours ago

Check point inhibitors Your case was a NepSAP / Board question. Check point inhibitors themselves do not cause TIN; but they "lower the thresho...

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RE: IgA Nephropathy Dual Immunotherapy 16 hours ago

Drs. Rodby and Singer raise an important conundrum for guideline writers in this ultra-dynamic landscape of therapy for IgAN. The ficus is moving a...

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RE: Pembrolizumab (Keytruda) AIN question 16 hours ago

Difficult decision. Can you provide further information concerning the preventative use of Pembrolizumsb in this case. Was he judged to be at low ,...

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RE: IgA Nephropathy Dual Immunotherapy 16 hours ago

Given how quickly the IgA nephropathy treatment landscape is evolving since the 2025 KDIGO guidelines were published, I think the best path forward...

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RE: IgA Nephropathy 20 hours ago

thank you! ------------------------------ Raman Anam MD Assistant Professor of Medicine LSU Health Shreveport Shreveport LA (786)266- 9110 ------...

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RE: Intradialytic hypertension 20 hours ago

Carvedilol is not the best beta blocker for HTN. Best beta blocker in hypertensive patients is Nevibolol if you have it in your area. ----------...

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RE: Intradialytic hypertension 21 hours ago

Unless your patient was under 35 kg UF should be slow enough. Do not know UF rates for 2/week , 13 ml/kg is for 3/ week. In my training years ( 197...

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Pembrolizumab (Keytruda) AIN question 21 hours ago

Dear Open Forum: Recently, I was referred a generally healthy 58 yo, 90 kg WM, who was found to have left sided 10.6 cm x 8.6 cm x 8 cm T3 RCCA in ...

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RE: IgA Nephropathy Dual Immunotherapy 22 hours ago

I'm not so sure that "Eventually this kind of data will emerge, but now such use should be discouraged except by N =1 trials, or enrollment in o...

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RE: IgA Nephropathy Dual Immunotherapy 23 hours ago

Dr. Dastooe- i agree tahr suggestions to use combination Immunosuppressive -antiinflammiry agents agents for high or very high risk IgAN is mainly ...

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RE: Intradialytic hypertension 1 day ago

This patient as mentioned still passes around 1 liter of urine per day. His Nett UF per session is hence around 1.5 liters over 4 hours . I was ...

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RE: IgA Nephropathy Dual Immunotherapy 1 day ago

Going back to the original thread , why would you want to combine Nefecon with Sibrenlimab , instead of considering Nefecon/Sibeprenilamab with Ipt...

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RE: IgA Nephropathy Dual Immunotherapy 1 day ago

Of up to 17 glomeruli, 6 are globally sclerotic, while the remaining glomeruli are enlarged and show mild to moderate mesangial matrix expansion wi...

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RE: Intradialytic hypertension 1 day ago

How fast is ultrafiltration ? I try to limit to 10 ml/kg/hr; have seen a few Pt not tolerate well 13 now recommended. If I remember correctly rapid...

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RE: IgA Nephropathy 1 day ago

I fully agree with Dr. Rodby but the T1 lesions and low eGFR will likely impair the response to steroids (+ MMF). Basic supportive care, probably i...

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RE: IgA Nephropathy 1 day ago

Thank you Dr. Rodby for the reply. He doesn't have any contraindications for steroids so It makes sense. ------------------------------ Raman An...

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RE: IgA Nephropathy Dual Immunotherapy 1 day ago

She has been on Losartan, labetalol for HTN prior to diagnosis of IgA nephropathy.. Pt did not tolerate other BP classes in the past. So far, no K ...

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RE: IgA Nephropathy Dual Immunotherapy 1 day ago

Unfortunately, BP, Na restriction are suboptimal.. BP ~ 130s-140s/ 80s Few spikes in the 150s-160s per BP log review ----------------------------...

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RE: Intradialytic hypertension 1 day ago

always a tough problem Running to holiday party but will Attache a couple reviews on the topic I'd start with the most recent ...

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RE: IgA Nephropathy 1 day ago

Sounds very advanced yet kidneys normal sized tough call but with proliferation, maybe worth a try as you pointed out There are so many new...

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IgA Nephropathy 1 day ago

26 YO caucasian seen him first time as an inpatient consult yesterday and did the biopsy for proteinuria, RBC casts and elevated creatinine and the...

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Intradialytic hypertension 2 days ago

Have a 35 year old male who has recently started IHD 2x/ week . He passes around 1 liter of urine per day. His current dry weight is 73 kg and he i...

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RE: IgA Nephropathy Dual Immunotherapy 2 days ago

Agree with Dr. Rubin. The label for Sparsentan requires that ARB or ACEi be stopped when Sparsentan is prescribed. ------------------------------...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

No Lasix was given ------------------------------ Katafan Achkar MD, FASN Houston Methodist Hospital and CLS Health Webster TX (832) 469-1166 ---...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

Just curious. Was this a lasix-MAG 3? We need to remember that MAG3 reflects effective renal plasma flow, not GFR (unlike DTPA). A 60/40 split is c...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

I think this case highlights the importance of looking for an abnormal genetic variant in the proband. This has already been mentioned in the previ...

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RE: IgA Nephropathy Dual Immunotherapy 2 days ago

What is the rationale of using DEARA and losartan? ------------------------------ Mario Rubin, M.D. Houston TX (713) 252-5539 ------------------...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

We did MAG3 Split function, RT kidney 60%, left kidney 40% Also, I attached an image of both kidneys ------------------------------ Kata...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

Thank you Dr Achkar. If the CT was enhanced with contrast then it is comparable to MRI, so if done with contrast then no need to obtain MRI. Both w...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

Thank you Dr. Chebib and everyone for your input. The donor does not have any hepatic and pancreatic cysts. The CT report of the mother states: Liv...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

Thank you Dr. Glassock. The left kidney volume seems normal (average 140ml and physiologically 5-10% larger than right) . The right kidney volume i...

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RE: IgA Nephropathy Dual Immunotherapy 2 days ago

Quite a favorable response to Iptacopan. The persistence of proteinuria of 1.5gns/ day, resistant to Sparsentan is a concern but in all likelihood ...

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RE: IgA Nephropathy Dual Immunotherapy 2 days ago

Yes, pt on sparsentan, SGLT2i, Losartan Hematuria resolved after adding Fabhalta --------------------------------- Ashraf Mohammed MD, MBBS Las...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

Thanks Dr. Chebib for elegant elegant analysis of a complex case. I wonder how you would interpret the high degree of asymmetry in kidney volume in...

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RE: Potential kidney donor older than 40, likely pathogenic PKD1 mutation and no cysts on CT scan of the abdomen 2 days ago

Interesting case. Thanks for sharing. I would hold off on allowing kidney donation until the case is resolved. The potential donor does not ha...

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RE: Minimal change disease relapse after steroid discontinuation despite on cyclosporine 2 days ago

Dr. Venturelli - Yes, VEXAS was excluded by genetic testing after that initial biopsy. Thanks for the advice about the 24-h urine testing; I did in...

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RE: Minimal change disease relapse after steroid discontinuation despite on cyclosporine 2 days ago

Thank you so much Dr. Rodby!! Very useful references. ------------------------------ Kelly Liang MD, MS, FASN Kansas City KS (507) 269-7812 ----...

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RE: Minimal change disease relapse after steroid discontinuation despite on cyclosporine 2 days ago

I recently looked into response time with rituximab (granted rituximab alone, firstline) for recurrent podocytopathy. What is reported in resp...

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